Firefox 3.0: the first 15 minutes
One problem: the new "smart locater bar" is bloated out the wazoo. I'm used to being able to see the last dozen URLs I typed in by hand; now they've cluttered that up. Fortunately, on day one of the release someone has already published the OldBar extension to fix it. I love open interfaces and large user communities. Hey, it's already up to version 1.2. :-)
I haven't figured out how to disable the star icon that, on single click, bookmarks the current page. I prefer to be a little more intentional about my bookmarking, and that icon is too close to other things I want to click on.
I expected that some add-ons might not be compatable with the new version; that always happens. IE Tab and the PDF viewer were fixed while I was typing this. But Firefox 3 is also picky now; Convo is compatable but Firefox won't install it because it does not provide for secure updates. Bah -- let that be my decision, Mozilla, not yours. Ask me; don't lock me out. I won't be upgrading my home machine or laptop until this is addressed.
The buttons in the toolbar are, um, "special". I haven't yet figured out how to change them to something that's easier to see. The gray treatment might be trendy and all, but it doesn't work in a reverse-video environment, and I expect to see something in every button slot even if that button is not currently available/meaningful. Right now I've got a big expanse of black where my "stop" button should be. That works because I know that's the "stop" slot, but I shouldn't have to know that. I sure don't know all the various things that show up along the bottom of the frame, for instance.
Amazon's site has some problems in 3.0 -- the search dialogue isn't doing the right things with colors. Typing light text in a box with a white background is no good. This worked yesterday in Firefox 2; I didn't check right before upgrading, so I can't say for sure that it's not Amazon's bug, but I don't think so. (Hmm... on the other hand, I can't find my wish list on the main page either now, and that's probably not Firefox's doing. I was going there at all to test a library-lookup plugin; that'll have to wait.)
That's the quick look.

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I've had bad experiences with the part of Amazon that deals with web-site issues, so I haven't asked them for debugging help this time. I mean, if they blew me off in response to "your site has been taking more than a minute per page to load for a week", why would I expect a better response now? (I was pretty surprised and disappointed when that happened.) Yeah, it's probably due to some unfortunate combination of add-ons and browser features interacting with some quirk of their site design; other sites work fine in FF 3 and Amazon works fine in IE. I still think they ought to care about the lost business.